Promotion of oxidative phosphorylation by complex I-anchored carbonic anhydrases?

verfasst von

Hans Peter Braun, Niklas Klusch

Abstract

The mitochondrial NADH-dehydrogenase complex of the respiratory chain, known as complex I, includes a carbonic anhydrase (CA) module attached to its membrane arm on the matrix side in protozoans, algae, and plants. Its physiological role is so far unclear. Recent electron cryo-microscopy (cryo-EM) structures show that the CA module may directly provide protons for translocation across the inner mitochondrial membrane at complex I. CAs can have a central role in adjusting the proton concentration in the mitochondrial matrix. We suggest that CA anchoring in complex I represents the original configuration to secure oxidative phosphorylation (OXPHOS) in the context of early endosymbiosis. After development of ‘modern mitochondria’ with pronounced cristae structures, this anchoring became dispensable, but has been retained in protozoans, algae, and plants.

Organisationseinheit(en)

Institut für Pflanzengenetik

Externe Organisation(en)

Max-Planck-Institut für Biophysik

Typ

Übersichtsarbeit

Journal

Trends in plant science

Band

29

Seiten

64-71

Anzahl der Seiten

8

ISSN

1360-1385

Publikationsdatum

01.2024

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Pflanzenkunde

Elektronische Version(en)

https://doi.org/10.1016/j.tplants.2023.07.007 (Zugang: Offen)
https://doi.org/10.15488/15380 (Zugang: Offen)