The key to unlock the Hsp100/Clp protein degradation machines of Mycobacterium

verfasst von

Noël Molière, Kürşad Turgay

Abstract

Hsp100/Clp protease complexes are molecular machines important for cellular protein homeostasis and are concurrently embedded in the control of various signal transduction networks by regulatory proteolysis. In Mycobacteria, the genes encoding the components of these Hsp100/Clp protease complexes are essential for growth and were identified as targets for antibiotics, with a new antimicrobial mechanism, that are active on slow growing or even dormant cells. Schmitz and Sauer (2014) report the biochemical characterization of mycobacterial Hsp100/Clp protease complexes actively degrading folded substrate proteins. Their results suggest an unusual activation mechanism for this protease complex and will set the stage for further mechanistic studies of antibiotics acting on this new cellular target. Copyright

Organisationseinheit(en)

Institut für Mikrobiologie

Typ

Meinungsbeitrag

Journal

Molecular microbiology

Band

93

Seiten

583-586

Anzahl der Seiten

4

ISSN

0950-382X

Publikationsdatum

30.06.2014

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Mikrobiologie, Molekularbiologie

Elektronische Version(en)

https://doi.org/10.1111/mmi.12696 (Zugang: Geschlossen)