The life of plant mitochondrial complex I

authored by: Hans Peter Braun, Stefan Binder, Axel Brennicke, Holger Eubel, Alisdair R. Fernie, Iris Finkemeier, Jennifer Klodmann, Ann Christine König, Kristina Kühn, Etienne Meyer, Toshihiro Obata, Markus Schwarzländer, Mizuki Takenaka, Anja Zehrmann
Abstract: The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.
Organisation(s): Institute of Plant Genetics
Section Plant Molecular Biology and Plant Proteomics
External Organisation(s): Ulm University
Max Planck Institute of Molecular Plant Physiology (MPI-MP)
Ludwig-Maximilians-Universität München (LMU)
Humboldt-Universität zu Berlin
University of Bonn
Type: Article
Journal: MITOCHONDRION
Volume: 19
Pages: 295-313
No. of pages: 19
ISSN: 1567-7249
Publication date: 21.02.2014
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Molecular Medicine, Molecular Biology, Cell Biology
Electronic version(s): https://doi.org/10.15488/11656 (Access: Open)
https://doi.org/10.1016/j.mito.2014.02.006 (Access: Closed)