The biosynthesis of pyoverdines

authored by: Michael T. Ringel, Thomas Brüser
Abstract: Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants. Prominent examples include pathogenic or non-pathogenic species such as Pseudomonas aeruginosa, P. putida, P. syringae, or P. fluorescens. Many distinct pyoverdines have been identified, all of which have a dihydroxyquinoline fluorophore in common, derived from oxidative cyclizations of non-ribosomal peptides. These serve as precursor of pyoverdines and are commonly known as ferribactins. Ferribactins of distinct species or even strains often differ in their sequence, resulting in a large variety of pyoverdines. However, synthesis of all ferribactins begins with an L-Glu/D-Tyr/L-Dab sequence, and the fluorophore is generated from the D-Tyr/L-Dab residues. In addition, the initial L-Glu residue is modified to various acids and amides that are responsible for the range of distinguishable pyoverdines in individual strains. While ferribactin synthesis is a cytoplasmic process, the maturation to the fluorescent pyoverdine as well as the tailoring of the initial glutamate are exclusively periplasmic processes that have been a mystery until recently. Here we review the current knowledge of pyoverdine biosynthesis with a focus on the recent advancements regarding the periplasmic maturation and tailoring reactions.
Organisation(s): Institute of Microbiology
Type: Article
Journal: Microbial Cell
Volume: 5
Pages: 424-437
No. of pages: 14
Publication date: 10.2018
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Immunology and Microbiology (miscellaneous) , Biochemistry, Genetics and Molecular Biology (miscellaneous)
Electronic version(s): https://doi.org/10.15698/mic2018.10.649 (Access: Open)
https://doi.org/10.15488/4731 (Access: Open)