Kürşad Turgay studied Chemistry at the TU Berlin and received his Dr. rer. nat. from the Philipps University Marburg, where he worked with Mohamed Marahiel on non-ribosomal peptide synthetases. For his postdoctoral research he went to David Dubnau's lab at the Public Health Research Institute then in NYC, where he worked on the control of competence development by regulated proteolysis in Bacillus subtilis. Next he joined the lab of Bernd Bukau - first at the University of Freiburg and then at the ZMBH of the University of Heidelberg - to continue his studies on proteolysis.
Kürşad Turgay has since been a Junior Professor and a Heisenberg Fellow of the DFG at the Institute for Biology - Microbiology of the FU Berlin. He is a Professor of Microbiology here at the Leibniz University in Hanover.
- Bacillus subtilis
- general and regulatory proteolysis
- AAA+ protease complexes
- function and mechanism of ClpCP and its adaptor proteins
- function of the adaptor and protein arginine kinase McsB
- chaperones and protein quality control
- stress response and regulation
- interplay of chaperone and protease systems
- function of HSP90 (HtpG)
Molière, N., Hoßmann, J., Schäfer, H. & Turgay, K. (2016) Role of Hsp100/Clp protease complexes in controlling the regulation of motility in Bacillus subtilis. Front. Microbiol. 7:315. doi: 10.3389/fmicb.2016.00315
Runde, S., Molière, N., Heinz, A., Maisonneuve, E., Janczikowski, A., Elsholz, A.K.W., Gerth, U., Hecker, M. & Turgay, K. (2014) The role of thiol oxidative stress response in heat-induced protein aggregate formation during thermotolerance in Bacillus subtilis. Mol. Microbiol. 91:1036-52.
Elsholz, A., Turgay, K., Michalik, S., Hessling, B., Gronau, K., Oertel, D., Mäder, U., Bernhardt, J., Becher, D., Hecker, M. & Gerth, U. (2012) Global impact of protein arginine phosphorylation on the physiology of Bacillus subtilis. Proc. Natl. Acad. Sci. USA 109: 7451-56.
Fuhrmann, J., Schmidt, A., Spiess, S., Lehner, A., Turgay, K., Mechtler, K., Charpentier, E. & Clausen, T. (2009) McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR. Science 324:1323-27.
Kirstein, J., Hoffmann, A., Lilie, H., Schmidt, R., Rübsamen-Waigmann, H., Brötz-Oesterhelt, H., Mogk, A. & Turgay, K. (2009) The antibiotic ADEP reprograms ClpP, switching it from a regulated to an uncontrolled protease. EMBO Mol Med 1:37-49
Kirstein, J., Strahl, H., Moliere, N., Hamoen, L.W. & Turgay, K. (2008) Localization of general and regulatory proteolysis in Bacillus subtilis cells. Mol. Microbiol. 70:682-694
Haslberger, T., Zdanowicz, A., Brand, I., Kirstein, J., Turgay, K., Mogk, A. & Bukau, B. (2008) Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments. Nat. Struct. Mol. Biol. 15:641-50.
Erbse, A.H., Wagner, J.N., Truscott, K.N., Spall, S.K., Kirstein, J., Zeth, K., Turgay, K., Mogk, A., Bukau, B. & Dougan, D.A. (2008) Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding. FEBS J. 275:1400-10.
Kirstein, J., Dougan, D.A., Gerth, U., Hecker, M. & Turgay, K. (2007) The tyrosine kinase McsB is a regulated adaptor protein for ClpCP. EMBO J. 26:2061-70.
Kirstein, J., Schlothauer, T., Dougan, D.A., Lilie, H., Tischendorf, G., Mogk, A., Bukau, B. & Turgay, K. (2006) Adaptor protein controlled oligomerization activates the AAA+ protein ClpC. EMBO J. 25:1481-91.
Andersson, F.I., Blakytny, R., Kirstein, J., Turgay, K., Bukau, B., Mogk, A. & Clarke, A.K. (2006) Cyanobacterial ClpC/Hsp100 protein displays intrinsic chaperone activity. J. Biol. Chem. 281:5468-75.
Kirstein, J., Zühlke, D., Gerth, U., Turgay, K. & Hecker, M. (2005) A tyrosine kinase and its activator control the activity of the CtsR heat shock repressor in B. subtilis. EMBO J. 24: 3435-45.
Schlothauer, T., Mogk, A:, Dougan, D.A., Bukau, B. & Turgay, K. (2003) MecA, an adaptor protein necessary for ClpC chaperone activity. Proc. Natl. Acad. Sci. USA 100:2306-11.
Turgay, K., Persuh, M., Hahn, J. & Dubnau, D. (2001) Roles of the two ClpC ATP binding sites in the regulation of competence and the stress response. Mol. Microbiol. 42: 717-727.
Persuh, M., Turgay, K., Mandic-Mulec, I. & Dubnau, D. (1999) The N- and the C-terminal domains of MecA recognize different partners in the competence molecular switch. Mol. Microbiol. 33: 886-94.
Turgay, K., Hahn, J., Burghoorn, J. & Dubnau, D. (1998) Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor. EMBO J. 17: 6730-38.
Chong, P.P., Podmore, S.M., Kieser, H.M., Redenbach, M., Turgay, K., Marahiel, M.A., Hopwood, D.A. & Smith, C.P. (1998) Physical identification of a chromosomal locus encoding biosynthetic genes for the lipopeptide calcium-dependent antibiotic (CDA) of Streptomyces coelicor A3(2). Microbiology 144: 193-199.
Turgay, K., Hamoen, L.W., Venema, G. & Dubnau, D. (1997) Biochemical characterization of a molecular switch involving the heat shock protein ClpC, which controls the activity of ComK, the competence transcription factor of Bacillus subtilis. Genes & Dev. 11: 119-128.
Turgay, K. & Marahiel, M.A. (1995) The gtcRS operon coding for two-component system regulatory proteins is located adjacent to the grs operon of Bacillus brevis. DNA Sequence 5: 283-290.
Turgay, K. & Marahiel, M.A. (1994) A general approach for identifying and cloning of peptide synthetase genes. Peptide Res. 7: 238-241.
Turgay, K., Krause, M. & Marahiel, M.A. (1992) Four homologous domains in the primary structure of GrsB are related to domains in a superfamily of adenylate forming enzymes. Mol. Microbiol. 6: 529-546.
Kohne, B., Marquardt, P., Praefcke, K., Psaras, P., Stephan, W. & Turgay, K. (1986) Monothioscyllitol ethers as discogens and double discogens. Chimia 40: 360-2
Moliere, N. & Turgay, K. (2014) The key to unlock the Hsp100/Clp protein degradation machines of Mycobacterium. Mol. Microbiol. 93: 583-86.
Mijakovic, I., Grangeasse, C. & Turgay, K. (2016) Exploring the diversity of protein modifications: special bacterial phosphorylation systems. FEMS Microbiol Rev 40: 398-417
Kirstein, J., Moliere, N., Dougan, D.A. & Turgay K. (2009) Adapting the machine: Adaptor proteins for Hsp100/Clp and AAA+ proteases. Nat. Rev. Microbiol. 7:589-99
Hengge, R. & Turgay, K. (2009) Proteolysis in prokaryotes - from molecular machines to a systems perspective. Res. Microbiol. 160: 615-617 (Editorial: Special issue on proteolysis in prokaryotes: protein quality control and regulatory principles. Edited by Regine Hengge and Kürsad Turgay)
Moliere, N. & Turgay, K. (2009) Chaperone-Protease Systems in Regulation and Protein Quality Control in Bacillus subtilis. Res. Microbiol. 160: 637-644.
Kirstein, J. & Turgay, K. (2005) A new Tyrosine Phosphorylation Mechanism Involved in Signal Transduction in Bacillus subtilis. J. Mol. Microbiol. Biotechnol. 9:182-188.
Mogk, A., Dougan, D.A., Weibezahn, J., Schlieker, C., Turgay, K. & B. Bukau. (2004) Broad yet high substrate specificity: the challenge of AAA+ proteins, J. Struct. Biol. 146: 90-98.
Dougan, D.A., Mogk A., Zeth K., Turgay, K. & Bukau B. (2002) AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett. 529: 6-10.
Moliere, N. & Turgay, K. (2013) General and Regulatory Proteolysis in Bacillus subtilis; p 73-103 In: "Regulated Proteolysis in Microorganisms" Subcellular Biochemistry Volume 66, D.A. Dougan (ed.) (Springer Netherlands)
Turgay, K. (2012) General and Regulatory Proteolysis in Bacillus subtilis; p 187-214 In: "Bacillus: Cellular and Molecular Biology", 2nd ed., P.L. Graumann ed. (Norfolk, UK: Caister Academic Press)
Turgay K. (2011) Role of Proteolysis and Chaperones in Stress Response and Regulation p 75-90 In: Bacterial Stress Responses (Second Edition), G. Storz & R. Hengge, eds. (Washington, DC: American Society for Microbiology).
Turgay, K. (2010) Regulatory proteolysis and signal transduction in bacteria, p 449-462 In: Bacterial Signaling. R. Krämer and K. Jung (eds.), (Weinheim: Wiley VCH Verlag).
Turgay, K. (2007) General and Regulatory Proteolysis in Bacillus subtilis; p 215-246 In: "Bacillus: Cellular and Molecular Biology", P.L. Graumann ed. (Norfolk, UK: Caister Academic Press)
Dubnau, D. & Turgay, K. (2000) The regulation of competence in Bacillus subtilis and its relation to stress response, p 249-260 In: Bacterial Stress Response, G. Storz & R. Hengge-Aronis, eds. (Washington, DC: American Society for Microbiology).
Turgay, K. (2007), "Adaptor mediated activation of the Hsp100/ Clp protein ClpC controls general and regulatory proteolysis in Bacillus subtilis", in Houry, W. (ed.), Molecular Chaperones: Principles and Diseases, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at www.hstalks.com)