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Research in the Tschowri group

Our research themes:

  • Cyclic di-GMP signalling and regulation in bacterial cell differentiation
  • Cyclic di-AMP enzymes and effectors in Streptomyces stress response
  • Bacterial multicellularity and cell fate decisions
  • Nukleotide signals in bacterial carbon storage
  • Small molecule signalling in Streptomyces’ cell division

Prof. Dr. rer. nat. Natalia Tschowri

Natalia Tschowri studied Biology at the Freie Universität Berlin, where she also obtained her PhD with a thesis on blue light signalling in the control of biofilm formation in Escherichia coli. In September 2012 she joined Prof. Mark Buttner’s lab at the John Innes Centre in Norwich, UK, as a PostDoc. Funded by the EMBO longterm fellowship, she began to work on c-di-GMP signalling in Streptomyces. Back in Berlin, she continued with her studies on the role of cyclic di-nucleotides in Streptomyces developmental biology as an Emmy Noether-Programme-funded group leader at the Humboldt-Universität zu Berlin. Since October 2020, she is a professor for cellular micobiology at the LUH.

The Faculty of Natural Sciences welcomes Natalia Tschowri [in German]


Wörmann ME, Tschowri N. Zyklische Dinukleotide als molekulare Entwicklungsbremse.
BIOspektrum. 2020 September 05; 26:482-484. doi.org/10.1007/s12268-020-1430-2

Haist J, Neumann SA, Al-Bassam MM, Lindenberg S, Elliot MA, Tschowri N.
Specialized and shared functions of diguanylate cyclases and phosphodiesterases
in Streptomyces development. Mol Microbiol. 2020 Aug 14. doi: 10.1111/mmi.14581.
Epub ahead of print.

Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, Kaever V, Findlay KC, Witte
G, Tschowri N. c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes
differentiation of multicellular bacteria. Proc Natl Acad Sci U S A. 2020 Mar
31;117(13):7392-7400. doi: 10.1073/pnas.1917080117.

Latoscha A, Wörmann ME, Tschowri N. Nucleotide second messengers in
Streptomyces. Microbiology. 2019 Nov;165(11):1153-1165. doi: 10.1099/mic.0.000846.

Kettles RA, Tschowri N, Lyons KJ, Sharma P, Hengge R, Webber MA, Grainger DC.
The Escherichia coli MarA protein regulates the ycgZ-ymgABC operon to inhibit
biofilm formation. Mol Microbiol. 2019 Nov;112(5):1609-1625. doi:

McLean TC, Lo R, Tschowri N, Hoskisson PA, Al Bassam MM, Hutchings MI, Som
NF. Sensing and responding to diverse extracellular signals: an updated analysis
of the sensor kinases and response regulators of Streptomyces species.
Microbiology. 2019 Sep;165(9):929-952. doi: 10.1099/mic.0.000817.

Hengge R, Häussler S, Pruteanu M, Stülke J, Tschowri N, Turgay K. Recent
Advances and Current Trends in Nucleotide Second Messenger Signaling in
Bacteria. J Mol Biol. 2019 Mar 1;431(5):908-927. doi: 10.1016/j.jmb.2019.01.014.

Al-Bassam MM, Haist J, Neumann SA, Lindenberg S, Tschowri N. Expression
Patterns, Genomic Conservation and Input Into Developmental Regulation of the
GGDEF/EAL/HD-GYP Domain Proteins in Streptomyces. Front Microbiol. 2018
Oct 23;9:2524. doi: 10.3389/fmicb.2018.02524.

Schumacher MA, Zeng W, Findlay KC, Buttner MJ, Brennan RG, Tschowri N. The
Streptomyces master regulator BldD binds c-di-GMP sequentially to create a
functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res. 2017 Jun
20;45(11):6923-6933. doi: 10.1093/nar/gkx287.

Tschowri N. Cyclic Dinucleotide-Controlled Regulatory Pathways in
Streptomyces Species. J Bacteriol. 2016 Jan 1;198(1):47-54. doi:

Bush MJ, Tschowri N, Schlimpert S, Flärdh K, Buttner MJ. c-di-GMP signalling
and the regulation of developmental transitions in streptomycetes. Nat Rev
Microbiol. 2015 Dec;13(12):749-60. doi: 10.1038/nrmicro3546.

St-Onge RJ, Haiser HJ, Yousef MR, Sherwood E, Tschowri N, Al-Bassam M,
Elliot MA. Nucleotide second messenger-mediated regulation of a muralytic enzyme
in Streptomyces. Mol Microbiol. 2015 May;96(4):779-95. doi: 10.1111/mmi.12971.

Tschowri N, Schumacher MA, Schlimpert S, Chinnam NB, Findlay KC, Brennan RG,
Buttner MJ. Tetrameric c-di-GMP mediates effective transcription factor
dimerization to control Streptomyces development. Cell. 2014 Aug
28;158(5):1136-1147. doi: 10.1016/j.cell.2014.07.022.

Tschowri N, Lindenberg S, Hengge R. Molecular function and potential
evolution of the biofilm-modulating blue light-signalling pathway of Escherichia
coli. Mol Microbiol. 2012 Sep;85(5):893-906. doi:

Mika F, Busse S, Possling A, Berkholz J, Tschowri N, Sommerfeldt N, Pruteanu
M, Hengge R. Targeting of csgD by the small regulatory RNA RprA links stationary
phase, biofilm formation and cell envelope stress in Escherichia coli. Mol
Microbiol. 2012 Apr;84(1):51-65. doi: 10.1111/j.1365-2958.2012.08002.x.

Sommerfeldt N, Possling A, Becker G, Pesavento C, Tschowri N, Hengge R. Gene
expression patterns and differential input into curli fimbriae regulation of all
GGDEF/EAL domain proteins in Escherichia coli. Microbiology. 2009
Apr;155(Pt 4):1318-1331. doi: 10.1099/mic.0.024257-0.

Tschowri N, Busse S, Hengge R. The BLUF-EAL protein YcgF acts as a direct
anti-repressor in a blue-light response of Escherichia coli. Genes Dev. 2009 Feb
15;23(4):522-34. doi: 10.1101/gad.499409.

Culham DE, Vernikovska Y, Tschowri N, Keates RA, Wood JM, Boggs JM.
Periplasmic loops of osmosensory transporter ProP in Escherichia coli are
sensitive to osmolality. Biochemistry. 2008 Dec 23;47(51):13584-93. doi:

Pesavento C, Becker G, Sommerfeldt N, Possling A, Tschowri N, Mehlis A,
Hengge R. Inverse regulatory coordination of motility and curli-mediated
adhesion in Escherichia coli. Genes Dev. 2008 Sep 1;22(17):2434-46. doi: