Cyclic Dinucleotide-Controlled Regulatory Pathways in Streptomyces Species

authored by

Natalia Tschowri

Abstract

The cyclic dinucleotides cyclic 3′,5′-diguanylate (c-di-GMP) and cyclic 3′,5′-diadenylate (c-di-AMP) have emerged as key components of bacterial signal transduction networks. These closely related second messengers follow the classical general principles of nucleotide signaling by integrating diverse signals into regulatory pathways that control cellular responses to changing environments. They impact distinct cellular processes, with c-di-GMP having an established role in promoting bacterial adhesion and inhibiting motility and c-di-AMP being involved in cell wall metabolism, potassium homeostasis, and DNA repair. The involvement of c-dinucleotides in the physiology of the filamentous, nonmotile streptomycetes remained obscure until recent discoveries showed that c-di-GMP controls the activity of the developmental master regulator BldD and that c-di-AMP determines the level of the resuscitation-promoting factor A(RpfA) cell wall-remodelling enzyme. Here, I summarize our current knowledge of c-dinucleotide signaling in Streptomyces species and highlight the important roles of c-di-GMP and c-di-AMP in the biology of these antibiotic-producing, multicellular bacteria.

Organisation(s)

Institute of Microbiology

Type

Article

Journal

Journal of bacteriology

Volume

198

Pages

47-54

No. of pages

8

ISSN

0021-9193

Publication date

01.01.2016

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Molecular Biology, Microbiology

Electronic version(s)

https://doi.org/10.1128/JB.00423-15 (Access: Unknown)